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The American Civil Liberties Union filed a request for precautionary measures with the Organization of American States' Inter-American Commission on Human Rights showing that the execution of John Winfield, scheduled for June 18, 2014 in the state of Missouri, will cause irreparable harm should it go forward. The ACLU asks that the executions be stayed until the IACHR can review and rule on the ACLU's petition that alleges Mr. Winfield's death sentence violates international law. On June 6, 2014, the IACHR granted ACLU request for precautionary measures against the United States and requested that "the Government of the United States to abstain from executing John Winfield until the IACHR has ruled on the merits of the individual petition filed on his behalf."

The American Civil Liberties Union filed a petition with the Organization of American States' Inter-American Commission on Human Rights showing that the upcoming executions by lethal injection in Missouri and Oklahoma will violate international law against cruel and unusual punishment, should they go forward. The ACLU asks that the executions be stopped until the IACHR can conduct independent investigations of the two cases.

In March 2014, the ACLU urged the Inter-American Commission on Human Rights (IACHR) to rule that sentencing children to mandatory life without the possibility of parole violates the Declaration of the Rights of Man and universal human rights principles. This hearing was held in response to a February 2006 petition from the ACLU and several other organizations to the IACHR, alleging that the human rights of juveniles sentenced to life without parole were being violated.

A groundbreaking school desegregation case in Hartford, Connecticut.